Title:       	Growth inhibition of 833K cells
Growth inhibition of 833K teratocarcinoma cells during 96 hours' exposure
T C Chou, R J Motzer, Y Tong, G Bosl.  Journal of the National Cancer
Institute, Vol 86, No. 20, Oct. 19, 1994.

Date:        	Aug 1996
Investigator:	Sample 6
Filename:    	sample6.csn
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Summary table
Drug	Combination Index Values at
	ED50	ED75	ED90	Dm	m	r
Paclit.	N/A	N/A	N/A	0.00217	1.24783	0.99013
(Not a combination)
Cispl.	N/A	N/A	N/A	0.32016	1.45990	0.98600
(Not a combination)
Topot.	N/A	N/A	N/A	0.04621	1.85486	0.99103
(Not a combination)
Pac/Cis	0.88749	0.78105	0.69014	0.00115	1.57160	0.99995
(1:100)
Cis/Top	0.55701	0.56153	0.56969	0.10535	1.58782	0.98948
(10:1)
Pac/Top	1.12570	0.92342	0.77247	0.00166	1.89081	0.99896
(1:10)
3 drugs	1.15003	0.73771	0.47959	0.00116	3.36336	0.98405
(1:100:10)
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Drug:	Paclit.
Comment:	Paclitaxel

Data points entered:
Paclit.	Fraction affected
然
0.002	0.4290
0.004	0.7080
0.005	0.7610
0.01	0.8820
0.02	0.9320

Median-effect parameters:
	Paclit.
	然
Dm:	0.00217
lower 95%:	0.00036
upper 95%:	0.01318

m:	1.24783 +/- 0.101953
y-int:	3.32420 +/- 0.228955
r:	0.99013
CCSI: 	0.98828
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Drug:	Cispl.
Comment:	Cisplatin

Data points entered:
Cispl.	Fraction affected
然
0.05	0.0550
0.1	0.2330
0.2	0.3010
0.5	0.5590
1	0.8210
2	0.9530

Median-effect parameters:
	Cispl.
	然
Dm:	0.32016
lower 95%:	0.20720
upper 95%:	0.49469

m:	1.45990 +/- 0.123465
y-int:	0.72212 +/- 0.092427
r:	0.98600
CCSI: 	0.66791
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Drug:	Topot.
Comment:	Topotecan

Data points entered:
Topot.	Fraction affected
然
0.01	0.0690
0.02	0.2130
0.05	0.3730
0.1	0.7850
0.2	0.9400
0.5	0.9910

Median-effect parameters:
	Topot.
	然
Dm:	0.04621
lower 95%:	0.02116
upper 95%:	0.10093

m:	1.85486 +/- 0.125056
y-int:	2.47666 +/- 0.162720
r:	0.99103
CCSI: 	0.89662
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Drug:	Pac/Cis
Comment:	Paclitaxel/Cisplatin
Combination:	Paclit.	Cispl.
Ratio:	1:100

Data points entered:
Paclit.	Cispl.	Fraction affected
(然)	(然)
0.001	0.1	0.4500
0.002	0.2	0.7010
0.005	0.5	0.9100
0.01	1	0.9680

Median-effect parameters:
	Paclit.	Cispl.
	(然)	(然)
Dm:	0.00115	0.11471
lower 95%:	0.00097	0.09667
upper 95%:	0.00136	0.13613

m:	1.57160 +/- 0.010928
y-int:	4.62110 +/- 0.027636
r:	0.99995
CCSI: 	0.98861
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Drug:	Cis/Top
Comment:	Cisplatin/Topetecan
Combination:	Cispl.	Topot.
Ratio:	10:1

Data points entered:
Cispl.	Topot.	Fraction affected
(然)	(然)
0.05	0.005	0.3040
0.1	0.01	0.4130
0.2	0.02	0.6750
0.5	0.05	0.9240
1	0.1	0.9770

Median-effect parameters:
	Cispl.	Topot.
	(然)	(然)
Dm:	0.10535	0.01053
lower 95%:	0.05507	0.00551
upper 95%:	0.20154	0.02015

m:	1.58782 +/- 0.134026
y-int:	1.55189 +/- 0.108418
r:	0.98948
CCSI: 	0.81614
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Drug:	Pac/Top
Comment:	Paclitaxel/Topetecan
Combination:	Paclit.	Topot.
Ratio:	1:10

Data points entered:
Paclit.	Topot.	Fraction affected
(然)	(然)
0.001	0.01	0.2740
0.002	0.02	0.5790
0.005	0.05	0.9010
0.01	0.1	0.9650

Median-effect parameters:
	Paclit.	Topot.
	(然)	(然)
Dm:	0.00166	0.01661
lower 95%:	0.00077	0.00769
upper 95%:	0.00359	0.03589

m:	1.89081 +/- 0.060980
y-int:	5.25572 +/- 0.154207
r:	0.99896
CCSI: 	0.98861
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Drug:	3 drugs
Comment:	All three drugs
Combination:	Paclit.	Cispl.	Topot.
Ratio:	1:100:10

Data points entered:
Paclit.	Cispl.	Topot.	Fraction affected
(然)	(然)	(然)
0.001	0.1	0.01	0.4560
0.002	0.2	0.02	0.8060
0.003	0.3	0.03	0.9470
0.005	0.5	0.05	0.9950

Median-effect parameters:
	Paclit.	Cispl.	Topot.
	(然)	(然)	(然)
Dm:	0.00116	0.11616	0.01162
lower 95%:	4.6685e-005	0.00467	0.00047
upper 95%:	0.02890	2.89027	0.28903

m:	3.36336 +/- 0.429923
y-int:	9.87126 +/- 1.136333
r:	0.98405
CCSI: 	0.99531
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